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Cat Number: API129453618

FulvestrantZM 182780, ZD 9238, ICI 182780

CAS Number

129453-61-8

Description

Fulvestrant (ZM 182780) is an estrogen receptor (ER) antagonist (IC50=9.4 nM) and an agonist of GPR30. Fulvestrant has antitumor activity, inhibiting cell proliferation and inducing apoptosis and autophagy.

Molecular Formula

C32H47F5O3S

Molecular Weight

606.77

Smiles

[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])C3CCC(O)CC3C[C@@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)[C@@]21[H]

Purity

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

Ethanol: 30.3 mg/mL (50 mM)DMSO: 45 mg/mL (74.16 mM)10% DMSO+40% PEG300+5% Tween 80+45% Saline: 6.07 mg/mL (10 mM), In vivo: Suspension. Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.

Relative Density

1.201

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