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Cat Number: API1332837316

Fosifloxuridine nafalbenamideNUC-3373, NUC3373, NUC 3373

CAS Number

1332837-31-6

Description

Fosifloxuridine nafalbenamide (NUC 3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor. NUC-3373 has anticancer activity. NUC-3373 is a ProTide transformation of 5-FU that generates much higher concentrations of FUDR-MP in patients' cells.

Molecular Formula

C29H29FN3O9P

Molecular Weight

613.53

Smiles

O(P(OC[C@H]1O[C@H](C[C@@H]1O)N2C(=O)NC(=O)C(F)=C2)(N[C@H](C(OCC3=CC=CC=C3)=O)C)=O)C=4C5=C(C=CC4)C=CC=C5

Purity

0.9587

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

DMSO: 100 mg/mL (162.99 mM), Sonication is recommended.