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Cat Number: API265121048

Fosaprepitant dimeglumine

CAS Number

265121-04-8

Description

Fosaprepitant dimeglumine (MK-0517) is the dimeglumine salt form of fosaprepitant, a water-soluble, N-phosphorylated prodrug of aprepitant with antiemetic activity. Upon intravenous administration and rapid conversion to aprepitant, this agent selectively binds to human substance P/neurokinin 1 (NK1) receptors in the central nervous system (CNS), inhibiting receptor binding of endogenous substance P and preventing substance P-induced emesis.

Molecular Formula

C37H56F7N6O16P

Molecular Weight

1004.83

Smiles

CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.C[C@@H](O[C@H]1OCCN(CC2NN(C(=O)[NH]2)P(O)(O)=O)[C@H]1C1CCC(F)CC1)C1CC(CC(C1)C(F)(F)F)C(F)(F)F

Purity

0.9875

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

DMSO: 185 mg/mL (184.1 mM)Ethanol: < 1 mg/mL (insoluble or slightly soluble)H2O: 124 mg/mL (123.4 mM)

HOURS

Daily: 9.30 AM–6.00 PM
Sunday : 9.30 AM–1.00 PM
Holidays: Closed

INFORMATION