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Cat Number: API915087331

EnzalutamideMDV3100

CAS Number

915087-33-1

Description

Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist (IC50=36 nM in LNCaP) that activates autophagy, exhibits antitumor activity, and is commonly used in treating desmoplasia-resistant prostate cancer.

Molecular Formula

C21H16F4N4O2S

Molecular Weight

464.44

Smiles

S=C1N(C(C)(C)C(=O)N1C2=CC(C(F)(F)F)=C(C#N)C=C2)C3=CC(F)=C(C(NC)=O)C=C3

Purity

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)DMSO: 60 mg/mL (129.19 mM)10% DMSO+40% PEG300+5% Tween 80+45% Saline: 8.5 mg/mL (18.3 mM), In vivo: Suspension. Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.

Relative Density

1.49

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