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Cat Number: API2216712660

ElexacaftorVX-445

CAS Number

2216712-66-0

Description

Elexacaftor (VX-445)is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector. It promotes the processing and trafficking of CFTR, increases the amount of CFTR on the cell surface, and improves the processing and trafficking of Phe508del CFTR protein.

Molecular Formula

C26H34F3N7O4S

Molecular Weight

597.65

Smiles

C(NS(=O)(=O)C1=CN(C)N=C1C)(=O)C2=C(N=C(C=C2)N3N=C(OCC(C(F)(F)F)(C)C)C=C3)N4C[C@@H](C)CC4(C)C

Purity

0.9987

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

DMSO: 125 mg/mL (209.15 mM), Sonication is recommended.