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Cat Number: API1051375166

DolutegravirS GSK1349572, GSK1349572

CAS Number

1051375-16-6

Description

Dolutegravir (GSK1349572) (IC50=2.7 nM), a two-metal-binding HIV integrase inhibitor, exhibits medium activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H.

Molecular Formula

C20H19F2N3O5

Molecular Weight

419.38

Smiles

C[C@@H]1CCO[C@H]2CN3CC(C(=O)NCC4CCC(F)CC4F)C(=O)C(O)C3C(=O)N12

Purity

0.9908

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)DMSO: 65 mg/mL (154.99 mM)H2O: < 1 mg/mL (insoluble or slightly soluble)

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