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Cat Number: API1110813314

DacomitinibPF-299804, PF-00299804, PF299

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APIs
CAS Number
1110813-31-4
Description
Dacomitinib (PF299)(PF299804; PF-00299804) is a highly selective, orally bioavailable small-molecule inhibitor of the HER family of tyrosine kinases with IC50 of 6, 45.7 and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively.
Molecular Formula
C24H25ClFN5O2
Molecular Weight
469.94
Smiles
COC1CC2NCNC(NC3CCC(F)C(Cl)C3)C2CC1NC(=O)\C=C\CN1CCCCC1
Purity
1
Storage
Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.
Solubility Information
1eq. HCl: 47 mg/mL (100 mM)DMSO: 45 mg/mL (95.76 mM)
Relative Density
1.344
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