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Cat Number: API1195765457

DabrafenibGSK2118436A, GSK2118436

CAS Number

1195765-45-7

Description

Dabrafenib (GSK2118436A) is a Raf inhibitor that inhibits C-Raf and B-RafV600E (IC50=5/0.6 nM) and is ATP-competitive. Dabrafenib exhibits antitumor activity for the treatment of B-RafV600E-mutated melanoma.

Molecular Formula

C23H20F3N5O2S2

Molecular Weight

519.56

Smiles

CC(C)(C)C1NC(C(s1)-C1CCNC(N)N1)-C1CCCC(NS(=O)(=O)C2C(F)CCCC2F)C1F

Purity

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.8 mg/mL (5.39 mM), In vivo: Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.DMSO: 55 mg/mL (105.86 mM)

Relative Density

1.443

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