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Cat Number: API877399525

CrizotinibPF-02341066

CAS Number

877399-52-5

Description

Crizotinib (PF-02341066) is an ATP-competitive small-molecule tyrosine kinase inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptors.

Molecular Formula

C21H22Cl2FN5O

Molecular Weight

450.34

Smiles

O([C@H](C)C1=C(Cl)C(F)=CC=C1Cl)C2=CC(C3=CN(N=C3)C4CCNCC4)=CN=C2N

Purity

0.9987

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

DMSO: 10 mg/mL (22.21 mM)10% DMSO+90% Saline: 1 mg/mL (2.22 mM), In vivo: Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.2eq.HCl: 45 mg/mL (100 mM)

Relative Density

1.475

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