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Cat Number: API934660932

CobimetinibRG7420, XL518, GDC-0973

CAS Number

934660-93-2

Description

Cobimetinib (GDC-0973) is a MEK1 inhibitor (IC50=4.2 nM) with selective and oral activity. Cobimetinib exhibits antitumor activity, inhibiting tumor cell proliferation and inducing apoptosis.

Molecular Formula

C21H21F3IN3O2

Molecular Weight

531.31

Smiles

C(=O)(C1=C(NC2=C(F)C=C(I)C=C2)C(F)=C(F)C=C1)N3C[C@](O)(C3)[C@@H]4CCCCN4

Purity

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)Ethanol: 44 mg/mL (82.8 mM)DMSO: 16.67 mg/mL (31.37 mM)

Relative Density

1.706

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