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Cat Number: API842133180

CanagliflozinJNJ 24831754ZAE, JNJ 28431754AAA, TA 7284, JNJ 28431754

CAS Number

842133-18-0

Description

Canagliflozin (JNJ 28431754AAA) is a selective SGLT2 inhibitor that inhibits CHO cells expressing mSGLT2, rSGLT2, and hSGLT2 (IC50=2/3.7/4.4 nM). Canagliflozin can be used for the treatment of type II diabetes mellitus (T2DM).

Molecular Formula

C24H25FO5S

Molecular Weight

444.52

Smiles

O[C@H]1[C@@H](O[C@H](CO)[C@@H](O)[C@@H]1O)C2=CC(CC=3SC(=CC3)C4=CC=C(F)C=C4)=C(C)C=C2

Purity

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)DMSO: 50 mg/mL (112.48 mM)Ethanol: < 1 mg/mL (insoluble or slightly soluble)

Relative Density

1.364

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