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Cat Number: API1817759424

Cabozantinib hydrochlorideXL184, Cabozantinib hydrochloride (849217-68-1(free base)), BMS-907351

CAS Number

1817759-42-4

Description

Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM).

Molecular Formula

C28H25ClFN3O5

Molecular Weight

537.96

Smiles

Cl.COC1CC2NCCC(OC3CCC(NC(=O)C4(CC4)C(=O)NC4CCC(F)CC4)CC3)C2CC1OC

Purity

0.9709

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

DMSO: 5.38 mg/mL (10 mM), Sonication is recommended.

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