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Cat Number: API606143899

BinimetinibARRY-438162, ARRY-162, MEK162

CAS Number

606143-89-9

Description

Binimetinib (ARRY-162) is a MEK1/2 inhibitor (IC50=12 nM) with selective and oral activity. Binimetinib has antitumor activity for the treatment of metastatic melanoma that cannot be resected or has a BRAF V600E or V600K mutation.

Molecular Formula

C17H15BrF2N4O3

Molecular Weight

441.23

Smiles

CN1CNC2C(F)C(NC3CCC(Br)CC3F)C(CC12)C(=O)NOCCO

Purity

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

DMSO: 50 mg/mL (113.32 mM)Ethanol: < 1 mg/mL (insoluble or slightly soluble)H2O: < 1 mg/mL (insoluble or slightly soluble)

Relative Density

1.67

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