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Cat Number: API1703793343

AvapritinibBLU-285

CAS Number

1703793-34-3

Description

Avapritinib (BLU-285) is a selective, highly potent, and orally active inhibitor of KIT and PDGFRA activation loop mutant kinases, targeting KIT D816V (IC50:0.27 nM) and PDGFRA D842V (IC50:0.24 nM), and attenuates the transport functions of ABCB1 and ABCG2. It binds to the active conformation of the kinases and exhibits antitumor activity.

Molecular Formula

C26H27FN10

Molecular Weight

498.56

Smiles

CN1CC(CN1)-C1CC2C(NCNN2C1)N1CCN(CC1)C1NCC(CN1)[C@@](C)(N)C1CCC(F)CC1

Purity

0.997

Storage

,Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

H2O: InsolubleEthanol: 3 mg/mLDMSO: 100 mg/mL (200.58 mM)