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Cat Number: API1217486617

AlpelisibBYL-719

CAS Number

1217486-61-7

Description

Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity, inhibiting PI3Kβ/γ/δ with low activity (IC50=250/290/1200 nM). Alpelisib demonstrates antitumor activity and specifically targets PIK3CA mutant tumors.

Molecular Formula

C19H22F3N5O2S

Molecular Weight

441.47

Smiles

CC1NC(NC(=O)N2CCC[C@H]2C(N)=O)sC1-C1CCNC(C1)C(C)(C)C(F)(F)F

Purity

0.9973

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

DMSO: 60 mg/mL (135.91 mM)10% DMSO+40% PEG300+5% Tween 80+45% Saline: 8.2 mg/mL (18.57 mM), In vivo: Suspension. Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.Ethanol: 2 mg/mL (4.53 mM)

Relative Density

1.391

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