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Cat Number: API850140737

Afatinib DimaleateBIBW2992, BIBW 2992MA2, Afatinib (BIBW2992) Dimaleate, Afatinib

CAS Number

850140-73-7

Description

Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (ErbB; EGFR) family, with antineoplastic activity.

Molecular Formula

C32H33ClFN5O11

Molecular Weight

718.08

Smiles

OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.CN(C)C\C=C\C(=O)NC1CC2C(NC3CCC(F)C(Cl)C3)NCNC2CC1O[C@H]1CCOC1

Purity

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)DMSO: 50 mg/mL (69.63 mM)Ethanol: < 1 mg/mL (insoluble or slightly soluble)

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