An ISO9001 Certified Supplier of Pharmaceutical Ingredients and Specialty Chemicals

Cat Number: API1231929977

AbemaciclibLY2835219, CDK4 6 dual inhibitor

CAS Number

1231929-97-7

Description

Abemaciclib (LY2835219) is a dual inhibitor of CDK4/6 (IC50=2/10 nM) with selectivity and specificity. Abemaciclib has antitumor activity and is used to treat advanced or metastatic breast cancer.

Molecular Formula

C27H32F2N8

Molecular Weight

506.59

Smiles

C(C)(C)N1C=2C(=C(F)C=C(C2)C3=NC(NC4=CC=C(CN5CCN(CC)CC5)C=N4)=NC=C3F)N=C1C

Purity

0.9987

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

DMSO: 2.17 mg/mL (4.28 mM), Sonication is recommended.Ethanol: 1.69 mg/mL (3.34 mM）, Sonication is recommended.10% DMSO+90% Saline: 0.1 mg/mL (0.2 mM), In vivo: Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.

Relative Density

1.32 (Predicted)

HOURS

Daily: 9.30 AM–6.00 PM
Sunday : 9.30 AM–1.00 PM
Holidays: Closed

INFORMATION

Tel:
E-mail:
Address:
WhatsAPP

Member of

CERTIFICATION