HGF

CHO Cells

Scatter Factor (SF), Hepatopoietin (HPTA)

Hepatocyte growth factor (HGF) is a potent, mesenchymal-derived mitogen of mature parenchymal hepatocytes and acts as a growth factor for a wide range of tissues and cell types.HGF signals through the transmembrane tyrosine kinase receptor of the MET.The functions of HGF include the induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and the enhancement of neuronal survival.HGF is a Crucial mitogen, especially after partial hepatectomy and other liver injuries.HGF, also known as scattering factor and hepatopoietin A, is a pleiotropic protein in the fibrinogen subfamily of S1 peptidases.

88~90 kDa (single chain), 59~61 kDa (alpha chain), 30~34 kDa (beta chain), on SDS-PAGE under reducing conditions.

Sterile Filtered White lyophilized (freeze-dried) powder.

> 95% as determined by SDS-PAGE.

ED50 < 10.0 ng/ml, measured in a cell proliferation assay using 4MBr5 cells, corresponding to a specific activity of > 1.0 × 105 units/mg.

< 0.2 EU per 1μg of the protein

Lyophilized after extensive dialysis against PBS.