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Cat Number: 92803ES

PTHrP

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Source

E.coli

Synonyms

Parathormone, Parathyrin

Description

PTHrP, also named parathyroid hormone-related protein, is belonging to the parathyroid hormone family. PTHrP is expressed in cancer cells (breast cancer, certain types of lung cancer including squamous cell lung carcinoma). The receptor for PTHrP is PTHR1. PTHrP plays a central role in regulating the hypercalcemia. Recombinant human PTHrP is a 9.9 kDa linear polypeptide of 86 amino acid residues and it shares 86 % a.a. identity with mouse PTHLH.

Molecular Weight

Approximately 9.9 kDa.

AA sequence

AVSEHQLLHD KGKSIQDLRR RFFLHHLIAE IHTAEIRATS EVSPNSKPSP NTKNHPVRFG SDDEGRYLTQ ETNKVETYKE QPLKTP

Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Purity

>98% by SDS-PAGE and HPLC analyses.

Endotoxin

< 0.1 EU per 1μg of the protein

Formulation

Lyophilized from a 0.2 μm filtered concentrated solution in 10 mM PB, pH 6.0, 300 mM NaCl.