Prednicarbate

Inquiry

Cat Number

API73771047

CAS Number

73771-04-7

If you have any other questions, please contact our experts.

Product Detail Description Advanced Innovations Customer Q&A

CAS Number

73771-04-7

EINECS

277-590-3

Storage

2-8℃

Synonyms

[2-(17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] propanoate

Molecular Formula

C27H36O8

Molecular Weight

488.6

Smiles

CCC(=O)OCC(=O)[C@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)C=C[C@]34C)O)C)OC(=O)OCC

Appearance

White to off-white solid

Boiling Point

640.7℃

Relative Density

1.25

pKa

14.05

General Description

Prednicarbate is a synthetic corticosteroid of the diester class, belonging to the glucocorticoid family of steroidal anti-inflammatory agents. Its structure features a prednisolone skeleton with a 17-propionate and 21-ethyl carbonate esterification, which modulates its topical potency and pharmacokinetic profile. The diesterification contributes to enhanced lipophilicity and targeted local activity with reduced systemic absorption.

Mechanism of Action

Prednicarbate acts through binding to the glucocorticoid receptor (GR), translocating to the nucleus, and modulating the expression of anti-inflammatory and immunosuppressive genes. It inhibits phospholipase A2 (via lipocortin-1 induction), reduces the synthesis of prostaglandins, leukotrienes, and other inflammatory mediators. Its relatively selective local activity at recommended concentrations minimizes systemic glucocorticoid side effects.

Application

Prednicarbate is indicated for the topical treatment of inflammatory and pruritic dermatoses responsive to corticosteroid therapy, including atopic dermatitis, eczematous dermatitis, psoriasis, and allergic contact dermatitis.

Prednicarbate, a poorly water-soluble corticosteroid for atopic dermatitis, was loaded into mesoporous SBA-15 silica using ethanol as a safe solvent. Characterization by nitrogen adsorption (BET/BJH) showed a 24% decrease in surface area and 16% decrease in pore volume, confirming drug encapsulation inside pores without altering pore size. FTIR, elemental analysis, and thermogravimetry indicated ~5% drug loading.
XRD and DSC demonstrated that encapsulated prednicarbate remained amorphous, with no crystalline drug phase. Thermal analysis also revealed a protective effect, reducing the drug’s thermal decomposition rate. A validated HPLC-MS/MS method quantified drug release in Franz diffusion cells. The SBA-15 formulation released prednicarbate six times slower than a conventional cream, providing a modified release profile. This system offers potential benefits: improved chemical stability, reduced metabolism by cutaneous esterases, lower dosing frequency, and decreased risk of corticosteroid-related adverse events such as skin atrophy.

Fig. 1 SEM images of SBA-15 and pred/SBA-15 microparticles. (Neto H S.; et al. 2016)

References

Neto H S, et al. Inclusion of prednicarbate in the SBA-15 silica: Protective effect and analytical profile when incorporated in a semisolid pharmaceutical formulation. Journal of Thermal Analysis and Calorimetry, 2016, 123(3): 2297-2305.

What is the recommended storage condition for Prednicarbate?

It should be stored at 2-8°C in a well-sealed container, protected from moisture and direct light, to maintain its chemical integrity throughout the shelf life.

Is a Certificate of Analysis (COA) available for Prednicarbate?

Yes, a fully verified COA is issued for every batch and can be shared electronically. Additional documentation such as MSDS or impurity profiles may be requested separately.

What quantities of Prednicarbate are available for order?

We accommodate orders of varying scale, from small research quantities through bulk commercial supply. Contact our sales team to discuss pack sizes and volume pricing.

Does Prednicarbate have pharmacopoeial monograph compliance?

Material meeting applicable pharmacopoeial specifications or equivalent internal quality standards can be supplied; please contact us with your specific compendial requirements.

Is Prednicarbate suitable for use in regulated pharmaceutical processes?

Yes, it is manufactured under quality standards consistent with regulated pharmaceutical applications, including in-process controls and release testing aligned with industry requirements.