Custom Intermediates

The quality, purity, stability, and synthetic efficiency of pharmaceutical intermediates directly determine the safety, efficacy, production cost, and development timeline of the final API. A substandard intermediate can become a bottleneck in the entire drug development process, while a high-purity, structurally confirmed intermediate can accelerate drug development.

Protheragen Intermediate is not just a supplier of pharmaceutical intermediates; we are your strategic partner in overcoming drug development challenges and accelerating time-to-market. Leveraging profound expertise in chemical synthesis, advanced analytical technologies, and rigorous quality management systems, we are committed to providing global pharmaceutical companies, biotech firms, and research institutions with one-stop custom services for intermediates. Please feel free to contact us for any needs. Let's collaborate and accelerate the development of the next breakthrough drug.

Pharmaceutical Intermediates Lab

Our Services

Protheragen Intermediate offers thousands of intermediates across diverse categories to support your drug development needs. If our existing intermediates do not meet your requirements, our expert team will provide personalized custom services. From complex peptides to specialized chemical building blocks, we can precisely deliver high-purity, structurally complex key intermediates to accelerate your drug development process.

Custom Synthesis

Custom Pharmaceutical Intermediates

Proficient in synthesizing various complex structures, including but not limited to heterocyclic compounds, chiral molecules, aromatic compounds, aliphatic compounds, fluorides, and boronates. We begin with milligram-scale route exploration and progress to developing robust, scalable kilogram-scale production processes.

Custom Peptide Intermediates

Expertise in solid-phase peptide synthesis, liquid-phase peptide synthesis, fragment condensation, and complex modifications (phosphorylation, glycosylation, fluorescent labeling, incorporation of unnatural amino acids, etc.). Capable of synthesizing linear and cyclic peptides, ranging from short peptides to medium-length peptides.

Purification and Separation

Purification and Separation

Our advanced purification and separation technology platform allows us to tailor the optimal purification strategy based on the physicochemical properties of the intermediate and your purity requirements, ensuring delivery of high-purity intermediates that meet the stringent standards of subsequent drug development or production.

Analysis Services

Analysis Services

Structural confirmation and purity analysis are core to quality assurance. We provide comprehensive analytical characterization services to precisely determine molecular structure, purity, enantiomeric/diastereomeric excess, and generate Certificates of Analysis (CoA) containing detailed spectra and data.

Chemical-Physical Testing

Chemical-Physical Testing

In-depth understanding of an intermediate’s physicochemical properties is crucial for downstream development. We offer a full range of testing services, including melting point, density, optical rotation, solubility, logP, particle size distribution, and more. These key data points are vital for drug process development, formulation studies, etc.

Stability Testing

Stability Testing

We provide scientifically rigorous stability study services. Through accelerated and long-term stability testing, we evaluate the property changes of intermediates under various environmental conditions. This enables us to determine optimal storage conditions, retest periods, and provide a stability data package to support regulatory filing.

Our Technology Platform: Cutting-edge Platforms Powering Drug R&D
Chemical Synthesis Icon

Chemical Synthesis Platform

Equipment: Multifunctional reactors (covering low-temperature, high-temperature, high-pressure reactions), continuous flow chemistry equipment, etc.

Capabilities: Grignard reactions, coupling reactions (Suzuki, Negishi, Stille, Heck, etc.), chiral synthesis (asymmetric catalysis, enzymatic catalysis, resolution), heterocycle construction, protecting group chemistry, HTS-optimized synthesis.

Peptide Synthesis Icon

Peptide Synthesis Platform

Equipment: Multi-channel parallel automated peptide synthesizers, large-scale synthesis reactors, and microwave peptide synthesizers, etc.

Capabilities: Fmoc/t-Boc solid-phase peptide synthesis, liquid-phase peptide synthesis, fragment condensation, and complex modifications (phosphorylation, glycosylation, lipidation, cyclization, fluorescent labeling, incorporation of unnatural amino acids, etc.).

Analysis & Purification Icon

Analysis and Purification Platform

Equipment: NMR, LC-MS, Prep-HPLC, SFC, GC-MS, PXRD, DSC, etc.

Capabilities: Atmospheric pressure/vacuum column chromatography, recrystallization, structure elucidation, purity determination, chiral analysis, solid-state characterization, etc.

Service Process

  1. Consultation & Quotation
  2. Agreement Execution & Payment
  3. Service Protocol Design & Confirmation
  4. Project Execution & Ongoing Communication
  5. Results Delivery
  6. Project Summary & Archiving
Service Process Visual