BPMPO
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CAS Number
1809289-04-0
Molecular Formula
C28H24N2O2
Molecular Weight
420.5
Relative Density
1.213±0.06
General Description
BPMPO is an effective oxalamide ligand for copper-catalyzed C–N coupling reactions, demonstrating particular utility in the amination of chloro-substituted sulfilimines. Its robust performance with aqueous ammonia as the ammonia source makes BPMPO a practical choice for challenging amination transformations in complex synthetic sequences.
Application
BPMPO serves as a reliable ligand for the synthesis of pharmaceutical intermediates, notably in the preparation of kinase inhibitor precursors through copper-catalyzed amination.
BPMPO is employed as an auxiliary ligand in a Cu-catalyzed C–N coupling that converts chloro-substituted sulfilimine into aniline. The reaction is run with 10 mol % CuI, 10 mol % BPMPO, aqueous NH3·H2O and K3PO4 in DMSO at 110 ℃ for 24 h, giving 91 % yield. This step is part of a short sequence that transforms the initial enantioenriched sulfilimine product (obtained via the Cu/NOBIN-picolinamide chemistry) into the known kinase-inhibitor precursor.
Fig. 1 BPMPO for the synthesis of kinase inhibitor. (He M.; et al. 2025)
References
- He M, et al. Assembly of (hetero) aryl sulfilimines via copper-catalyzed enantioselective S-arylation of sulfenamides with (hetero) aryl Iodides. Nature Communications, 2025, 16(1): 2310.
What is the BPMPO ligand used for?
BPMPO is used for Cu-catalyzed C-N couplings with high efficiency.
What are the key benefits of BPMPO?
High yield, use of aqueous ammonia, and a robust process.
What is the minimum order quantity for BPMPO?
MOQ varies. Please contact us for details.
What purity is BPMPO available in?
Available in different purity grades. Please inquire about details.
Do you have technical data for BPMPO?
Yes, please contact us for detailed technical information.
