Hydrocortamate Hydrochloride

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Cat Number

API125031

CAS Number

125-03-1

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Product Detail Description Customer Q&A

CAS Number

125-03-1

Synonyms

[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phChemicalbookenanthren-17-yl]-2-oxo-ethyl]2-diethylaminoacetatehydrochloride;17-Hydroxycorticosterone21-diethylaminoacetatehydrochloride

Molecular Formula

C27H42ClNO6

Molecular Weight

512.1

Smiles

CCN(CC)CC(=O)OCC(=O)[C@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)O)C)O.Cl

General Description

Hydrocortamate Hydrochloride is a corticosteroid ester prodrug that hydrolyzes to hydrocortisone in vivo. It belongs to the glucocorticoid class with combined mineralocorticoid and glucocorticoid receptor affinity.

Mechanism of Action

Hydrocortamate crosses cell membranes and binds cytosolic glucocorticoid receptors, forming complexes that translocate to the nucleus and modulate gene transcription via glucocorticoid response elements, downregulating inflammatory mediators.

Application

Used in the treatment of inflammatory, allergic, and autoimmune conditions. Hydrocortamate Hydrochloride is indicated for dermatological inflammation, rheumatoid arthritis exacerbations, and adrenal insufficiency replacement therapy.

How does Hydrocortamate Hydrochloride differ from direct hydrocortisone administration?

As an ester prodrug, Hydrocortamate provides modified pharmacokinetics with sustained release of hydrocortisone, offering prolonged anti-inflammatory activity.