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Exatecan

Inquiry

Cat Number

API197720539

CAS Number

197720-53-9

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Product Detail

CAS Number

197720-53-9

Synonyms

Exatecan mesylate hydrate exatecan mesylate dihydrate Exatecan mesylate [USAN]

Description

Exatecan Mesylate is a semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater potency than camptothecin and other camptothecin analogues. (NCI04)

Molecular Formula

C25H30FN3O9S

Molecular Weight

567.6

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