CXCL11-2

beta-R1, b-R1, chemokine (C-X-C motif) ligand 11, CXCL11, H174, H174IP9, Interferon gamma-inducible protein 9, Interferon-inducible T-cell alpha chemoattractant, ITAC

CXCL11 also known as I-TAC is belonging to the CXC chemokine family. CXCL11, together with MIG and IP-10, constitute a subset of chemokines that are ligands for CXCR3, a chemokine receptor that is primarily expressed on activated Th1 cells and NK cells. Mouse CXCL11 also shares 36% and 29% aa sequence identity with mouse IP-10 (Crg-2) and mouse MIG, respectively. CXCL11 binds CXCR3 with a higher affinity than CXCL10, suggesting that CXCL11 has the potential to restrain inflammatory autoimmunity. Similar to CXCL10, CXCL11 has been shown to be a chemoattractant for IL-2-activated T-lymphocytes, but not for isolated T-cells, neutrophils or monocytes.CXCL11 is not only a major effector for T cell chemotaxis in the pathophysiology of neuroinflammatory disorders, but also plays a crucial role in migration of activating T cells during IFN-dominated immune responses.

Approximately 9.1 kDa.

Sterile Filtered White lyophilized (freeze-dried) powder.

>98% by SDS-PAGE and HPLC analyses.